gd T Cells Regulate Major Histocompatibility Complex Class II (IA and IE)-Dependent Susceptibility to Coxsackievirus B3-Induced Autoimmune Myocarditis
نویسندگان
چکیده
S. A. HUBER,* J. E. STONE, D. H. WAGNER, JR., J. KUPPERMAN, L. PFEIFFER, C. DAVID, R. L. O’BRIEN, G. S. DAVIS, AND M. K. NEWELL Department of Pathology and Immunobiology Program and Pulmonary Disease and Critical Care Unit, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405; National Jewish Medical Research Center, Denver, Colorado 80206, and Department of Immunology, University of Colorado Health Sciences Center, Denver, Colorado 80262; and Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905
منابع مشابه
gamma delta+ T cells regulate major histocompatibility complex class II(IA and IE)-dependent susceptibility to coxsackievirus B3-induced autoimmune myocarditis.
Coxsackievirus B3 (CVB3) infection induces myocardial inflammation and myocyte necrosis in some, but not all, strains of mice. C57BL/6 mice, which inherently lack major histocompatibility complex (MHC) class II IE antigen, develop minimal cardiac lesions despite high levels of virus in the heart. The present experiments evaluate the relative roles of class II IA and IE expression on myocarditis...
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Evidence has accumulated that T cell-mediated autoimmunity plays an important role in the pathogenesis of viral myocarditis. T lymphocytes are known to recognize antigen-presenting cells, such as virus-infected cells, being restricted by syngeneic major histocompatibility complex (MHC) antigens. To clarify in more detail the immunological mechanisms involved, we induced acute viral myocarditis ...
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